L-type calcium channel as a cardiac oxygen sensor
نویسندگان
چکیده
منابع مشابه
Cardiac L-type calcium channel (Cav1.2) associates with subunits
The cardiac voltage-gated Ca channel, Cav1.2, mediates excitation-contraction coupling in the heart. The molecular composition of the channel includes the pore-forming 1 subunit and auxiliary 2/ -1 and subunits. Ca channel subunits, of which there are 8 isoforms, consist of 4 transmembrane domains with intracellular Nand C-terminal ends. The 1 subunit was initially detected in the skeletal musc...
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The L-type calcium channel (LTCC) provides trigger Ca(2+) for sarcoplasmic reticulum Ca-release, and LTCC function is influenced by interacting proteins including the LTCC distal COOH terminus (DCT) and calmodulin. DCT is proteolytically cleaved and reassociates with the LTCC complex to regulate calcium channel function. DCT reduces LTCC barium current (I(Ba,L)) in reconstituted channel complex...
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Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel. Knockdown of Myoscape in cardiomyocytes decreases calcium transients associated with smaller Ca(2+) amplitudes and a lower diastolic Ca(2+) content. Likewise, L-type calcium channel currents are ...
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Ca(2+) entry is delicately controlled by inactivation of L-type calcium channel (LTCC) composed of the pore-forming subunit alpha1C and the auxiliary subunits beta1 and alpha2delta. Calmodulin is the key protein that interacts with the COOH-terminal motifs of alpha1C, leading to the fine control of LTCC inactivation. In this study we show evidence that a hyperpolarization-activated cyclic nucle...
متن کاملA model of graded calcium release and L-type Ca channel inactivation in cardiac muscle
Bondarenko, Vladimir E., Glenna C. L. Bett, and Randall L. Rasmusson. A model of graded calcium release and L-type Ca channel inactivation in cardiac muscle. Am J Physiol Heart Circ Physiol 286: H1154–H1169, 2004;10.1152/ajpheart.00168.2003.—We have developed a model of Ca handling in ferret ventricular myocytes. This model includes a novel L-type Ca channel, detailed intracellular Ca movements...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2010
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2009.05095.x